This year I made a conscious choice to have as little involvement in RFL as possible. After last year's cloying and overdone events schedule, where it was almost impossible to find a party/event/gig/product release that wasn't tied to RFL, there was also the guilt tripping of "why aren't you donating or doing laps"? On top of that was the fact it lasted for some 6 months. I know this is important but
nothing needs to last half of our year for a single event.
While it's probable that research into cures for various cancers will come into world wide use (though given the way pharmaceutical companies like to patent everything from genes to molecules, who knows) I prefer helping out charities who are doing things on an international scale. At this stage the RFL in SL is still for the benefit of the American Cancer Society. I am unable to find anything relating to international sharing or distribution of the money raised to I'm assuming it will all go to ACS. Nothing I've seen on any official SLRFL activity or group mentions an international effort or contribution.
This year's RFL has thankfully not been quite so in your face. Unfortunately the guilt tripping has reared it's head in a couple of places but some people seem unwilling or unable to understand that not everyone shares their fanaticism.
Cancer is a problem. I have several relatives who have been diagnosed with it and I've had friends lose parents to it, but I find it surprising that there are people treating this as the most important charity in the world. I'm happy to donate my lindens, when I have them, but a barrage of spam and guilt is more likely to have me ignore you completely regardless of how worthy your cause is.
I'm sure my comments may put a few noses out of joint, but it wouldn't be RFL without a little drama.
One thing about the actual Relay itself is that it brings out some excellent ideas in theme builds. This year we have inspirations from Willie Wonka, to Troy to things that sail and fly, here's my selection from the 2008 builds for RFL. Hopefully the sim crashes will be resolved by the time of the actual Relay. Not holding my breath though.

The City of Troy
Passionate Redheads theme park build

An Alice in Wonderland build by Oakie Doakies

SL M*A*S*H*

A King Arthur inspired build

Carusoe's Island. Built by Friday

The Green Lantern Core [sic]

Giant Snail Racing

Frozen Peas' giant garden. They should be wary of the giant snails down the road.

This was called "ACT Sailing Venice Elven". I'm not sure I see the connection but who knows.

The secret machine that powers Caledon

A lovely glass gazebo on the Caledon build

A wider view of the Caledon sim

Fairy Tales group.
The St. George's Dragon Annual Picnic & Knight Roast
Hansel & Gretal's Bakery

Rapunzel's Wig Shop.

Beauty's Mattress Mart.
There were some great ideas in this section. The Chinny Chin Inn and the Huff & Puff housing Co-op, and Lil' Red's clothing boutique were among others.

The Adventures of Mark Twain.

The Survivor's group. I'll admit I don't understand the imagery of the wagon on the cloud but it was a nice build

Designers for a Cure group's rather cute looking build

The HELP & Planning Committee Camp's African themed build

VBA's picnic build

More of the picnic

The extremely purple Wonka Factory. Purple was obviously the colour of choice this year.

New Babbage's Railway Station

Chester goes out for a bite in the Sailing For Life build

Some of the fishermen at Sailing For Life

Steelhead in miniature. Good for Godzilla AVs

With the giant Castle Wulfenbach flying overhead

Royal Bretons' wonderful recreation of Isaac Mendez's Studio from the TV series
Heroes.

The military encampment of Roma Pro Vita

Relay's Flying Aces. Complete with blimp tour of the sims.

Hogwart's Castle. This build is actually for auction.

The Avilion build

Radio Radio's Mysterious courtyard. This leads you to...

Sky Dalek! Let's see this turn up the next time someone plays Doctoring the Tardis. To give you an idea of scale the black splodge on the landing deck is me.

Flash! Aaaa aahhhh!

Dr.
Flexi J Hans Zarkov's rocket ship.

Ming's Throne Room.
This is a good build in that it also includes sound samples from the movie. The heavy drumbeat should help propel relay lappers through the section.